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- Title
Pilot study of Panax quinquefolius (American ginseng) to improve cancer-related fatigue: a randomized, double-blind, dose-finding evaluation: NCCTG trial N03CA.
- Authors
Barton DL; Soori GS; Bauer BA; Sloan JA; Johnson PA; Figueras C; Duane S; Mattar B; Liu H; Atherton PJ; Christensen B; Loprinzi CL; Barton, Debra L; Soori, Gamini S; Bauer, Brent A; Sloan, Jeff A; Johnson, Patricia A; Figueras, Cesar; Duane, Steven; Mattar, Bassam
- Abstract
<bold>Purpose: </bold>This pilot trial sought to investigate whether any of three doses of American ginseng (Panax quinquefolius) might help cancer-related fatigue. A secondary aim was to evaluate toxicity.<bold>Methods: </bold>Eligible adults with cancer were randomized in a double-blind manner, to receive American ginseng in doses of 750, 1,000, or 2,000 mg/day or placebo given in twice daily dosing over 8 weeks. Outcome measures included the Brief Fatigue Inventory, vitality subscale of the Medical Outcome Scale Short Form-36 (SF-36), and the Global Impression of Benefit Scale at 4 and 8 weeks.<bold>Results: </bold>Two hundred ninety patients were accrued to this trial. Nonsignificant trends for all outcomes were seen in favor of the 1,000- and 2,000-mg/day doses of American ginseng. Area under the curve analysis of activity interference from the Brief Fatigue Inventory was 460-467 in the placebo group and 750 mg/day group versus 480-551 in the 1,000- and 2,000-mg/day arms, respectively. Change from baseline in the vitality subscale of the SF-36 was 7.3-7.8 in the placebo and the 750-mg/day arm, versus 10.5-14.6 in the 1,000- and 2,000-mg/day arms. Over twice as many patients on ginseng perceived a benefit and were satisfied with treatment over those on placebo. There were no significant differences in any measured toxicities between any of the arms.<bold>Conclusion: </bold>There appears to be some activity and tolerable toxicity at 1,000-2,000 mg/day doses of American ginseng with regard to cancer-related fatigue. Thus, further study of American ginseng is warranted.
- Publication
Supportive Care in Cancer, 2010, Vol 18, Issue 2, p179
- ISSN
0941-4355
- Publication type
journal article
- DOI
10.1007/s00520-009-0642-2