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- Title
The impact of injector-based contrast agent administration in time-resolved MRA.
- Authors
Budjan, Johannes; Attenberger, Ulrike I.; Schoenberg, Stefan O.; Pietsch, Hubertus; Jost, Gregor
- Abstract
<bold>Objectives: </bold>Time-resolved contrast-enhanced MR angiography (4D-MRA), which allows the simultaneous visualization of the vasculature and blood-flow dynamics, is widely used in clinical routine. In this study, the impact of two different contrast agent injection methods on 4D-MRA was examined in a controlled, standardized setting in an animal model.<bold>Methods: </bold>Six anesthetized Goettingen minipigs underwent two identical 4D-MRA examinations at 1.5 T in a single session. The contrast agent (0.1 mmol/kg body weight gadobutrol, followed by 20 ml saline) was injected using either manual injection or an automated injection system. A quantitative comparison of vascular signal enhancement and quantitative renal perfusion analyses were performed.<bold>Results: </bold>Analysis of signal enhancement revealed higher peak enhancements and shorter time to peak intervals for the automated injection. Significantly different bolus shapes were found: automated injection resulted in a compact first-pass bolus shape clearly separated from the recirculation while manual injection resulted in a disrupted first-pass bolus with two peaks. In the quantitative perfusion analyses, statistically significant differences in plasma flow values were found between the injection methods.<bold>Conclusions: </bold>The results of both qualitative and quantitative 4D-MRA depend on the contrast agent injection method, with automated injection providing more defined bolus shapes and more standardized examination protocols.<bold>Key Points: </bold>• Automated and manual contrast agent injection result in different bolus shapes in 4D-MRA. • Manual injection results in an undefined and interrupted bolus with two peaks. • Automated injection provides more defined bolus shapes. • Automated injection can lead to more standardized examination protocols.
- Subjects
MAGNETIC resonance imaging; COMPUTED tomography; BLOOD flow; CARDIOVASCULAR diseases; ANGIOGRAPHY; INJECTIONS; ANIMAL experimentation; BIOLOGICAL models; CHEMICAL elements; ORGANOMETALLIC compounds; SWINE; PRODUCT design; CONTRAST media; MAGNETIC resonance angiography; DRUG administration; DRUG dosage; EQUIPMENT &; supplies
- Publication
European Radiology, 2018, Vol 28, Issue 5, p2246
- ISSN
0938-7994
- Publication type
journal article
- DOI
10.1007/s00330-017-5178-0