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- Title
Interleaving cerebral CT perfusion with neck CT angiography part I. Proof of concept and accuracy of cerebral perfusion values.
- Authors
Oei, Marcel; Meijer, Frederick; Woude, Willem-Jan; Smit, Ewoud; Ginneken, Bram; Prokop, Mathias; Manniesing, Rashindra; Oei, Marcel T H; Meijer, Frederick J A; van der Woude, Willem-Jan; Smit, Ewoud J; van Ginneken, Bram
- Abstract
<bold>Objectives: </bold>We present a novel One-Step-Stroke protocol for wide-detector CT scanners that interleaves cerebral CTP with volumetric neck CTA (vCTA). We evaluate whether the resulting time gap in CTP affects the accuracy of CTP values.<bold>Methods: </bold>Cerebral CTP maps were retrospectively obtained from 20 patients with suspicion of acute ischemic stroke and served as the reference standard. To simulate a 4 s gap for interleaving CTP with vCTA, we eliminated one acquisition at various time points of CTP starting from the bolus-arrival-time(BAT). Optimal timing of the vCTA was evaluated. At the time point with least errors, we evaluated elimination of a second time point (6 s gap).<bold>Results: </bold>Mean absolute percentage errors of all perfusion values remained below 10 % in all patients when eliminating any one time point in the CTP sequence starting from the BAT. Acquiring the vCTA 2 s after reaching a threshold of 70HU resulted in the lowest errors (mean <3.0 %). Eliminating a second time point still resulted in mean errors <3.5 %. CBF/CBV showed no significant differences in perfusion values except MTT. However, the percentage errors were always below 10 % compared to the original protocol.<bold>Conclusion: </bold>Interleaving cerebral CTP with neck CTA is feasible with minor effects on the perfusion values.<bold>Key Points: </bold>• Removing a single CTP acquisition has minor effects on calculated perfusion values • Calculated perfusion values errors depend on timing of skipping a CTP acquisition • Qualitative evaluation of CTP was not influenced by removing two time points • Neck CTA is optimally timed in the upslope of arterial enhancement.
- Subjects
PERFUSION; STROKE diagnosis; COMPUTED tomography; ISCHEMIA; BLOOD circulation disorders; CEREBRAL angiography; CEREBRAL circulation; CEREBRAL ischemia; COMPARATIVE studies; DIAGNOSTIC imaging; RESEARCH methodology; MEDICAL cooperation; NECK; RESEARCH; STROKE; EVALUATION research; RETROSPECTIVE studies; MULTIDETECTOR computed tomography
- Publication
European Radiology, 2017, Vol 27, Issue 6, p2649
- ISSN
0938-7994
- Publication type
journal article
- DOI
10.1007/s00330-016-4577-y