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- Title
Comparison of ASL and DCE MRI for the non-invasive measurement of renal blood flow: quantification and reproducibility.
- Authors
Cutajar, Marica; Thomas, David; Hales, Patrick; Banks, T.; Clark, Christopher; Gordon, Isky
- Abstract
Objectives: To investigate the reproducibility of arterial spin labelling (ASL) and dynamic contrast-enhanced (DCE) magnetic resonance imaging (MRI) and quantitatively compare these techniques for the measurement of renal blood flow (RBF). Methods: Sixteen healthy volunteers were examined on two different occasions. ASL was performed using a multi-TI FAIR labelling scheme with a segmented 3D-GRASE imaging module. DCE MRI was performed using a 3D-FLASH pulse sequence. A Bland-Altman analysis was used to assess repeatability of each technique, and determine the degree of correspondence between the two methods. Results: The overall mean cortical renal blood flow (RBF) of the ASL group was 263 ± 41 ml min [100 ml tissue], and using DCE MRI was 287 ± 70 ml min [100 ml tissue]. The group coefficient of variation (CV) was 18 % for ASL and 28 % for DCE-MRI. Repeatability studies showed that ASL was more reproducible than DCE with CVs of 16 % and 25 % for ASL and DCE respectively. Bland-Altman analysis comparing the two techniques showed a good agreement. Conclusions: The repeated measures analysis shows that the ASL technique has better reproducibility than DCE-MRI. Difference analysis shows no significant difference between the RBF values of the two techniques. Key Points: • Reliable non-invasive monitoring of renal blood flow is currently clinically unavailable. • Renal arterial spin labelling MRI is robust and repeatable. • Renal dynamic contrast-enhanced MRI is robust and repeatable. • ASL blood flow values are similar to those obtained using DCE-MRI.
- Subjects
SPIN labels; CONTRAST-enhanced magnetic resonance imaging; BLOOD flow measurement; KIDNEY radiography; DIAGNOSTIC imaging research
- Publication
European Radiology, 2014, Vol 24, Issue 6, p1300
- ISSN
0938-7994
- Publication type
Article
- DOI
10.1007/s00330-014-3130-0