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- Title
Comparative diagnostic performance of ¹⁸F-FDG PET/CT versus whole-body MRI for determination of remission status in multiple myeloma after stem cell transplantation.
- Authors
Derlin T; Peldschus K; Münster S; Bannas P; Herrmann J; Stübig T; Habermann CR; Adam G; Kröger N; Weber C; Derlin, Thorsten; Peldschus, Kersten; Münster, Silvia; Bannas, Peter; Herrmann, Jochen; Stübig, Thomas; Habermann, Christian R; Adam, Gerhard; Kröger, Nicolaus; Weber, Christoph
- Abstract
<bold>Objectives: </bold>To compare the diagnostic performance of whole-body magnetic resonance imaging (WBMRI) versus (18)F-fluorodeoxyglucose ((18)F-FDG) positron emission tomography/computed tomography (PET/CT) for determination of remission status in patients with multiple myeloma (MM) after stem cell transplantation (SCT).<bold>Methods: </bold>Thirty-one patients were examined by both WBMRI and PET/CT after SCT. Imaging results and clinical remission status as determined by the clinical gold standard (Uniform Response Criteria) were compared.<bold>Results: </bold>One hundred four lesions were detected in 21 patients. PET/CT had a sensitivity of 50.0 %, a specificity of 85.7 %, a positive predictive value of 62.5 %, a negative predictive value of 78.3 %, and an overall accuracy of 74.2 % for determination of remission status. MRI had a sensitivity of 80.0 %, a specificity of 38.1 %, a positive predictive value of 38.1 %, a negative predictive value of 80 %, and an overall accuracy of 51.6 %. Concordant results were observed in only 12 (11.5 %) of the 104 lesions.<bold>Conclusions: </bold>In the post-treatment setting, both FDG PET/CT and WBMRI provide information about the extent of disease, allowing for a more comprehensive evaluation of persisting or recurrent myeloma. MRI may often be false positive because of persistent non-viable lesions. Therefore, PET/CT might be more suitable than MRI for determination of remission status.
- Publication
European Radiology, 2013, Vol 23, Issue 2, p570
- ISSN
0938-7994
- Publication type
journal article
- DOI
10.1007/s00330-012-2600-5