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- Title
Targeting tumor-associated macrophages in an experimental glioma model with a recombinant immunotoxin to folate receptor β.
- Authors
Nagai, Taku; Tanaka, Masashi; Tsuneyoshi, Yasuhiro; Baohui Xu; Michie, Sara A.; Hasui, Kazuhisa; Hirano, Hirofumi; Arita, Kazunori; Matsuyama, Takami
- Abstract
Tumor-associated macrophages (TAMs) are frequently found in glioblastomas and a high degree of macrophage infiltration is associated with a poor prognosis for glioblastoma patients. However, it is unclear whether TAMs in glioblastomas promote tumor growth. In this study, we found that folate receptor β (FRβ) was expressed on macrophages in human glioblastomas and a rat C6 glioma implanted subcutaneously in nude mice. To target FRβ-expressing TAMs, we produced a recombinant immunotoxin consisting of immunoglobulin heavy and light chain Fv portions of an anti-mouse FRβ monoclonal antibody and Pseudomonas exotoxin A. Injection of the immunotoxin into C6 glioma xenografts in nude mice significantly depleted TAMs and reduced tumor growth. The immunotoxin targeting FRβ-expressing macrophages will provide a therapeutic tool for human glioblastomas.
- Subjects
MACROPHAGES; TUMOR growth; ANTIBODY-toxin conjugates; MONOCLONAL antibodies; IMMUNOTHERAPY
- Publication
Cancer Immunology, Immunotherapy, 2009, Vol 58, Issue 10, p1577
- ISSN
0340-7004
- Publication type
Article
- DOI
10.1007/s00262-009-0667-x