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- Title
A significant linear association exists between advanced maternal age and adverse perinatal outcome.
- Authors
Salem Yaniv, Shimrit; Levy, Amalia; Wiznitzer, Arnon; Holcberg, Gershon; Mazor, Moshe; Sheiner, Eyal
- Abstract
Objective: The present study was aimed to investigate perinatal outcome of elderly nulliparous patients. Study design: A retrospective study was performed comparing pregnancy outcomes of nulliparous patients at three age groups: less than 35 years (reference group), 35-40 years, and above 40 years. The linear-by-linear association test was used to examine linear association between advanced maternal age and adverse pregnancy outcomes. A multiple logistic regression model was used to control for confounders. Results: Out of 45,033 nulliparous women with singleton gestations, 1,036 were of women over the age of 35, and 188 over 40. A significant linear association was documented between advanced maternal age and adverse outcomes, such as intra uterine growth restriction, low birth weight, congenital malformations, and perinatal mortality. Using a multiple logistic regression model, controlling for gestational age, IUGR and malformations, advanced maternal age was not found to be an independent risk factor for perinatal mortality (adjusted odds ratio = 1.04, 95% confidence interval 0.7-1.4). Conclusion: A significant linear association exists between advanced maternal age and adverse maternal and perinatal outcomes. Nevertheless, in our population, advanced maternal age is not an independent risk factor for perinatal mortality.
- Subjects
FETAL growth retardation; MATERNAL age; LOW birth weight; PREGNANCY complications; PERINATAL death; RETROSPECTIVE studies; MULTIPLE regression analysis
- Publication
Archives of Gynecology & Obstetrics, 2011, Vol 283, Issue 4, p755
- ISSN
0932-0067
- Publication type
Article
- DOI
10.1007/s00404-010-1459-4