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- Title
Electron microscopic observations of sural nerve in familial opticoacoustic nerve degeneration with polyneuropathy.
- Authors
Ohta, Michiya
- Abstract
Electron microscopic data are presented on a sural nerve biopsy from a patient with familial opticoacoustic nerve degeneration with polyneuropathy. This disease is not yet defined clinically, but is similar to Charcot-Marie-Tooth disease and Refsum's disease. Examination showed a hypertrophic neuropathy with onion-bulb formations. There was often abnormal elongation or an occasional circle of the basement membrane of a Schwann cell around the core of the onion-bulb. Degeneration of the myelin sheath and the axon, very rare remyelinative changes, and non-specific lipid deposits in the Schwann cell cytoplasm were observed. Unusual inclusions in the Schwann cells or accumulations in the endoneurium were not observed. Specific findings were not found in this study. These findings were considered to be those of the early changes of a chronic neuropathy.
- Publication
Acta Neuropathologica, 1970, Vol 15, Issue 2, p114
- ISSN
0001-6322
- Publication type
Article
- DOI
10.1007/BF00685265