We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Effect of obesity on fragility fractures, BMD and vitamin D levels in postmenopausal women. Influence of type 2 diabetes mellitus.
- Authors
de Tejada-Romero, M. J. Gómez; Saavedra-Santana, P.; de la Rosa-Fernández, F.; Suárez-Ramírez, N.; Martín-Martínez, A.; del Rosario, F. Martín; Sosa-Henríquez, M.
- Abstract
Aims: To see the effects of obesity on risk fracture, bone density (BMD), and vitamin D levels in a group of postmenopausal women, and consider how comorbid type 2 diabetes mellitus (T2DM) modifies them. Methods: 679 postmenopausal women were grouped into obese and non-obese. Obese women were grouped into those with T2DM and those without. 25(OH)-vitamin D, PTH and BMD were measured, and prevalent fragility fractures were gathered. Results: Obese women had higher prevalence of T2DM, than non-obese women. Levels of 25(OH)-vitamin D were lower and those of PTH higher in obese women, BMD values were higher in obese women. Diabetic-obese women had a higher prevalence of non-vertebral fractures than non-diabetic-obese. Multivariate logistic regression model showed association of fragility fractures with age, total hip BMD, BMI and T2DM. Obese women have higher BMD and lower 25(OH)-vitamin D values (and higher PTH) than non-obese, without diabetes. Conclusions: T2DM confers an increased risk of non-vertebral fractures in postmenopausal obese women.
- Subjects
BONE density; TYPE 2 diabetes; VITAMIN D; POSTMENOPAUSE; OVERWEIGHT women
- Publication
Acta Diabetologica, 2022, Vol 59, Issue 9, p1201
- ISSN
0940-5429
- Publication type
Article
- DOI
10.1007/s00592-022-01923-x