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- Title
Shift work and the onset of type 2 diabetes: results from a large-scale cohort among Japanese workers.
- Authors
Osaki, Yohei; Kuwahara, Keisuke; Hu, Huan; Nakagawa, Tohru; Yamamoto, Shuichiro; Honda, Toru; Mizoue, Tetsuya; Japan Epidemiology Collaboration on Occupational Health Study Group; Islam, Zobida; Akter, Shamima; Inoue, Yosuke; Okazaki, Hiroko; Miyamoto, Toshiaki; Ogasawara, Takayuki; Sasaki, Naoko; Uehara, Akihiko; Yamamoto, Makoto; Kochi, Takeshi; Eguchi, Masafumi; Shirasaka, Taiki
- Abstract
Aims: Data are limited regarding how shift work is linked to the development of type 2 diabetes, especially among workers at high risk of diabetes. We examined the risk of diabetes according to shift-work conditions over several years among Japanese adults. Methods: This prospective study enrolled 17,515 workers (age 40–78 years). Shift work was self-reported at annual health examinations over time from 2004 to 2017 and categorized as shift workers or non-shift workers. Diabetes was defined as fasting plasma glucose, random glucose, HbA1c, and self-reported use of antidiabetic medications. The association of shift work and diabetes was quantified using Cox regression. Results: During a follow-up of 8.1 years in median, 2071 incident cases of diabetes were documented. Compared with non-shift work, shift work showed a significantly elevated hazard ratios of developing diabetes. Shift work showed a 19% (95% confidence intervals: 3–37%) higher hazard ratios for diabetes, after adjustment for demographic-, cardiometabolic-, and work-related factors. Further adjustment for lifestyle factors and body mass index did not materially change this association (a 16% increase; 95% confidence intervals, 1–34%). This relationship was replicated among workers with prediabetes. Conclusions: Engaging in shift work may increase the risk of developing diabetes independently of lifestyle factors and body mass index, even among prediabetic workers.
- Subjects
TYPE 2 diabetes; SHIFT systems; PERIODIC health examinations; INFORMATION technology; BODY mass index
- Publication
Acta Diabetologica, 2021, Vol 58, Issue 12, p1659
- ISSN
0940-5429
- Publication type
Article
- DOI
10.1007/s00592-021-01770-2