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- Title
Differential inhibition of HIV-1 cell binding and HIV-1-induced syncytium formation by low molecular weight sulphated polysaccharides.
- Authors
Montefiori, David C.; Robinson, W. Edward; Modliszewski, Ann; Rowland, Jack M.; Schuffman, Shirley S.; Mitchell, William M.; Montefiori, D C; Robinson, W E; Modliszewski, A; Rowland, J M; Schuffman, S S; Mitchell, W M
- Abstract
Dextran sulphate (MW 5000 and 8000) and a polysulphated glycosaminoglycan (MW 10,000), at concentrations that provided complete protection in a homologous infection assay, failed to block syncytium formation and the resulting cytopathic effect when MT-2 cells were mixed with H9/HTV-1 cells. These substances also had no antiviral activity when added to cells, after virus challenge, at a time when binding and entry were complete. However, a high molecular weight (500,000) dextran sulphate blocked HIV-1 infection at both stages. Thus, the gp 120-CD4 interactions mediating HIV-1 binding and HIV-1-induced syncytium formation are differentially affected by this class of polyanionic substances. Furthermore, size may be a determining factor in their potential application as anti-HIV treatment.
- Publication
Journal of Antimicrobial Chemotherapy (JAC), 1990, Vol 25, Issue 3, p313
- ISSN
0305-7453
- Publication type
journal article