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- Title
THE LINK BETWEEN LIPOPROTEIN(A) AND ACUTE CORONARY SYNDROMES IN PATIENTS WITH DIABETES.
- Authors
Popoaia, Ana; Rodean, Ioana-Patricia; Halaţiu, Vasile-Bogdan; Pop-Bandrabula, Andreea-Oana; Rad, Cristina Maria; Benedek, Theodora
- Abstract
Background: Acute coronary syndromes (ACS) represent one of the main causes of mortality and morbidity worldwide, with their incidence continuously increasing due to associated risk factors. A risk factor that has recently come to the attention of the public is lipoprotein a [Lp(a)], which has been shown to be an important predictor of ischemic coronary disease. However, the role of Lp(a) in the etiopathogenesis of ACS in patients with diabetes mellitus (DM) is not yet fully known. Objective: The study aims to underline the link between Lp(a) and ACS in individuals with DM. Material and methods: The study included 196 consecutives patients admitted into the Cardiology Department of Emergency Clinical County Hospital Târgu Mureş with ACS, who underwent percutaneous coronary interventions. The patients were divided into two groups according to the presence of DM - Group 1, 109 patients without DM, and Group 2, 87 patients with DM. For all patients serum level of high sensitive C reactive protein (hsCRP), Lp(a), triglycerides (TG) were also assessed. Results : Patients with DM were significantly younger compared to those without DM (60.17 ± 7.03 vs 55.54 ± 14.36, p = 0.004), with no difference in terms of gender distribution (p=0.25), but the smoker status was more frequent found in patients without DM (p=0.008). Also, it was observed that patients with DM present a significantly higher inflammatory level (2.21 ± 0.35 mg/dL vs 5.64 mg/dL ± 0.75, p = 0.002) and triglyceride values (153.40 ± 20.68 mg/dL vs 239.90 ± 19.10 mg/dL, p<0.0001). Moreover, the Lp(a) seric levels in group 2 were significantly higher compared to group 1 (0.15 ± 0.09 g/L vs 0.33 ± 0.05 g/L, p<0.0001). Conclusions: Patients with concomitant ACS and DM are younger and showed a more pronounced serum Lp(a) level with a more exacerbated inflammatory status, while patients without DM were more prone to present the traditional risk factors for ACS.
- Subjects
ROMANIA; DIABETES complications; RISK assessment; LIPOPROTEINS; CONFERENCES &; conventions; ACUTE coronary syndrome; DISEASE risk factors
- Publication
Acta Marisiensis. Seria Medica, 2024, Vol 70, p19
- ISSN
2668-7755
- Publication type
Article