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- Title
Response to "Neuromelanin? MRI of Noradrenergic and Dopaminergic Neurons".
- Authors
He, Naying; Chen, Yongsheng; LeWitt, Peter A.; Yan, Fuhua; Haacke, Ewart Mark
- Abstract
In Keren's figure 5, they show a clear correlation between the density of staining of the tyrosine hydroxylase and LC neurons with the MR enhancement seen in the LC. Their excellent paper shows a colocation of NM cells in the LC that corresponds to norepinephrine neurons with the MTC NM-MRI data. Thus, LC/SN signal intensity is, although not attributable to NM, likely to correlate with NM (as well as with intracellular water) because NM as an effective metal chelator provides neuronal protection and decreases with NA/DA neuron loss.".
- Subjects
NORADRENERGIC neurons; DOPAMINERGIC neurons; LOCUS coeruleus; MAGNETIC resonance imaging; LEWY body dementia; ALZHEIMER'S disease
- Publication
Journal of Magnetic Resonance Imaging, 2023, Vol 58, Issue 1, p326
- ISSN
1053-1807
- Publication type
Letter to the Editor
- DOI
10.1002/jmri.28481