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- Title
The synthesis of DL-1-(hexadecanoyloxy)methyl- and 1- O-hexadecanoyl-inositols as potential inhibitors of phospholipase C.
- Authors
James, D.; Massy, R.; Wyss, Pierre
- Abstract
The synthesis of racemic analogues of phosphatidylinositol (PI) and phosphatidylinositol 4,5-bisphosphate (PIP2) starting from myo-inositol is described. Inositol derivatives with and without homologalion at C(l) and with and without ionic groups (phosphate or sulfate) at C(4) and C(5) were prepared as well as homologated derivatives with deoxy composition at C(2) and/or C(6). In all these compounds, palmitate ester groups were introduced in place of the diacylglyceryl group of PI or PIP2.
- Publication
Helvetica Chimica Acta, 1990, Vol 73, Issue 4, p1037
- ISSN
0018-019X
- Publication type
Article
- DOI
10.1002/hlca.19900730428