We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Early prediction of hypocalcemia following thyroid surgery. A prospective randomized clinical trial.
- Authors
Saba, Alessandra; Podda, Mauro; Messina Campanella, Antonio; Pisanu, Adolfo
- Abstract
Purpose: The aim of this randomized-controlled trial was to validate the results of a previous prospective single-cohort observational study conducted in the same surgical unit regarding the use of concomitant intact parathyroid hormone (iPTH) and serum calcium measurement in predicting hypocalcemia after total thyroidectomy. Methods: From January 2014 to January 2015, 150 patients underwent total thyroidectomy in our department and were randomized into two groups. The experimental group was submitted to iPTH assay 6 h after surgery while the control group was submitted to a daily assay of serum calcium and phosphorus. Sensitivity and specificity of different serum measurements have been calculated using the receiver-operator characteristics (ROC) curve. Results: The prevalence of hypocalcemia was 14.25% in both groups. The assay of iPTH 6 h after surgery combined with the serum calcium assay 24 h after surgery yielded the highest diagnostic accuracy in predicting hypocalcemia using ROC curves, with 100% sensitivity and 100% specificity. Conclusions: According to our previous study, the combined measurement of iPTH 6 h after surgery and of serum calcium 24 h after surgery are highly predictive of early postoperative hypocalcemia. These results are important in selecting the patients eligible for early discharge and those who need calcium and vitamin D supplementation.
- Subjects
HYPOCALCEMIA; THYROID gland surgery; RANDOMIZED controlled trials; PARATHYROID hormone; RECEIVER operating characteristic curves; VITAMIN D in human nutrition; DIAGNOSIS
- Publication
Langenbeck's Archives of Surgery, 2017, Vol 402, Issue 7, p1119
- ISSN
1435-2443
- Publication type
Article
- DOI
10.1007/s00423-017-1586-5