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- Title
Systems biology and gene networks in neurodevelopmental and neurodegenerative disorders.
- Authors
Parikshak, Neelroop N.; Gandal, Michael J.; Geschwind, Daniel H.
- Abstract
Genetic and genomic approaches have implicated hundreds of genetic loci in neurodevelopmental disorders and neurodegeneration, but mechanistic understanding continues to lag behind the pace of gene discovery. Understanding the role of specific genetic variants in the brain involves dissecting a functional hierarchy that encompasses molecular pathways, diverse cell types, neural circuits and, ultimately, cognition and behaviour. With a focus on transcriptomics, this Review discusses how high-throughput molecular, integrative and network approaches inform disease biology by placing human genetics in a molecular systems and neurobiological context. We provide a framework for interpreting network biology studies and leveraging big genomics data sets in neurobiology.
- Subjects
BIOLOGICAL systems; GENE regulatory networks; NEURODEVELOPMENTAL treatment; TREATMENT of neurodegeneration; NEURAL circuitry; HUMAN genetics; GENOMICS
- Publication
Nature Reviews Genetics, 2015, Vol 16, Issue 8, p441
- ISSN
1471-0056
- Publication type
Article
- DOI
10.1038/nrg3934