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- Title
EXPLORING THE NEUROPROTECTIVE EFFECTS OF SYNTHETIC COMPOUNDS FOR NEW NEURODRUG DEVELOPMENT.
- Authors
PICCIALLI, ILARIA; GRECO, FRANCESCA; VICIDOMINI, CATERINA; SISALLI, MARIA JOSÈ; TEDESCHI, VALENTINA; DI MOLA, ANTONIA; BORBONE, NICOLA; OLIVIERO, GIORGIA; DE FEO, VINCENZO; SECONDO, AGNESE; MASSA, ANTONIO; PANNACCIONE, ANNA; NOLLI, MARIA GRAZIA; EWERT, ERNEST; FIK-JASKÓLSKA, MARTA; ROVIELLO, GIOVANNI N.
- Abstract
Introduction: Alzheimer's disease (AD) presents significant therapeutic challenges, with amyloid β1-42 (Aβ1-42) protein aggregation playing a central role in its pathogenesis. Aim: Our study investigates the potential therapeutic efficacy of the isoindolinone derivative 3-(3-oxoisoindolin-1-yl)pentane-2,4-dione (ISOAC1) against Aβ1-42-induced toxicity. Material and methods: We employed spectroscopic and computational approaches to explore ISOAC1's ability to mitigate Aβ1-42 aggregation and its consequent toxicity. Other experimental analyses included Thioflavin T fluorescence assay, and Western blotting. Results: Our findings reveal ISOAC1's capacity to disrupt Aβ1-42 aggregation and hinder its transition towards β-sheet structures. Computational investigations elucidate ISOAC1's binding mechanisms with Aβ1-42, highlighting its potential as a therapeutic agent. Conclusions: ISOAC1 emerges as a promising neuroprotective compound, offering insights into novel therapeutic strategies for AD treatment. The combined spectroscopic and computational approach herein presented provides a comprehensive understanding of ISOAC1's mechanism of action against Aβ1-42-induced toxicity.
- Subjects
ALZHEIMER'S disease; AMYLOID; NEUROPROTECTIVE agents; WESTERN immunoblotting; TREATMENT effectiveness; THIOFLAVINS
- Publication
Medical Science Pulse, 2024, Vol 18, p27
- ISSN
2544-1558
- Publication type
Abstract