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- Title
LncRNA-Dependent Mechanisms of Transforming Growth Factor-β: From Tissue Fibrosis to Cancer Progression.
- Authors
Tang, Philip Chiu-Tsun; Zhang, Ying-Ying; Li, Jane Siu-Fan; Chan, Max Kam-Kwan; Chen, Jiaoyi; Tang, Ying; Zhou, Yiming; Zhang, Dongmei; Leung, Kam-Tong; To, Ka-Fai; Tang, Sydney Chi-Wai; Lan, Hui-Yao; Tang, Patrick Ming-Kuen
- Abstract
Transforming growth factor-β (TGF-β) is a crucial pathogenic mediator of inflammatory diseases. In tissue fibrosis, TGF-β regulates the pathogenic activity of infiltrated immunocytes and promotes extracellular matrix production via de novo myofibroblast generation and kidney cell activation. In cancer, TGF-β promotes cancer invasion and metastasis by enhancing the stemness and epithelial mesenchymal transition of cancer cells. However, TGF-β is highly pleiotropic in both tissue fibrosis and cancers, and thus, direct targeting of TGF-β may also block its protective anti-inflammatory and tumor-suppressive effects, resulting in undesirable outcomes. Increasing evidence suggests the involvement of long non-coding RNAs (lncRNAs) in TGF-β-driven tissue fibrosis and cancer progression with a high cell-type and disease specificity, serving as an ideal target for therapeutic development. In this review, the mechanism and translational potential of TGF-β-associated lncRNAs in tissue fibrosis and cancer will be discussed.
- Subjects
NON-coding RNA; CANCER invasiveness; EPITHELIAL-mesenchymal transition; LINCRNA; FIBROSIS; MYOFIBROBLASTS; INFLAMMATORY mediators
- Publication
Non-Coding RNA, 2022, Vol 8, Issue 3, p36
- ISSN
2311-553X
- Publication type
Article
- DOI
10.3390/ncrna8030036