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- Title
Association between the MLH1 gene and longevity.
- Authors
Dong Jo Kim; Sang Mi Yi; Seung Yeon Lee; Heun Soo Kang; Yoon-Ho Choi; Yeong Wook Song; Sang Chul Park
- Abstract
Perturbations in genomic stability result in cancer, a reduced life span, and premature aging. MLH1 is a mismatch repair enzyme that acts to maintain genomic stability, and a loss of MLH1 increases cancer incidence and apoptosis resistance, which suggests a link between MLH1 and longevity. We found here that MLH1 is associated with longevity by comparing a centenarian group with a control group. Our data indicate a critical role for MLH1 in longevity.
- Subjects
ENZYMES; GENES; MEDICAL genetics; LIFE expectancy; LONGEVITY; CANCER
- Publication
Human Genetics, 2006, Vol 119, Issue 3, p353
- ISSN
0340-6717
- Publication type
Article
- DOI
10.1007/s00439-006-0148-7