We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Survival after minimally invasive radical hysterectomy without using uterine manipulator for early-stage cervical cancer: A systematic review and meta-analysis.
- Authors
Rui-Zhe Li; Li-Fei Sun; Rui Li; Hong-Jing Wang
- Abstract
Background: Minimally invasive radical hysterectomy has been reported to increase the risk of cancer relapse and death compared with open surgery in women with early-stage cervical cancer. The use of a uterine manipulator is considered one of the risk factors. Objectives: To investigate whether women with early-stage cervical cancer treated with minimally invasive radical hysterectomy without using uterine manipulator have oncological outcomes similar to those of open surgery. Search strategy: Searches were performed in MEDLINE, Embase and CENTRAL from their inception until 31 March 2022. Selection criteria: Inclusion criteria were: (1) randomised controlled trials or observational cohort studies published in English, (2) studies comparing minimally invasive radical hysterectomy without using a uterine manipulator with open radical hysterectomy in women with early-stage cervical cancer, and (3) studies comparing survival outcomes. Data collection and analysis: Two authors independently conducted data extraction and assessed study quality. We calculated the hazard ratios (HR) and the 95% confidence intervals (CI) using the inverse variance approach for survival outcome. Main results: Six observational studies with 2150 women were included. The minimally invasive surgery group had a significantly higher risk of cancer relapse compared with open surgery group (HR 1.55, 95% CI 1.15–2.10). Conclusions: Minimally invasive radical hysterectomy without using a uterine manipulator resulted in an inferior recurrence-free survival compared with open radical hysterectomy in the treatment of women with early-stage cervical cancer.
- Subjects
TRACHELECTOMY; CERVICAL cancer; HYSTERECTOMY; MINIMALLY invasive procedures; CANCER relapse; SURVIVAL rate
- Publication
BJOG: An International Journal of Obstetrics & Gynaecology, 2023, Vol 130, Issue 2, p176
- ISSN
1470-0328
- Publication type
Article
- DOI
10.1111/1471-0528.17339