We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
High Level Estradiol Induces EBV Reactivation and EBV gp350/220(+)CD138(+) Double-positive B Cell Population in Graves' Disease Patients and Healthy Controls.
- Authors
Sayuri Hara; Keiko Nagata; Yuji Nakayama; Katsumi Higaki; Michiko Matsushita; Satoshi Kuwamoto; Masako Kato; Kazuhiko Hayashi
- Abstract
Graves' disease occurs predominantly in women. Epstein-Barr virus (EBV) mainly persists in human B lymphocytes, and its reactivation stimulates antibody production. We previously suggested that the EBV reactivation-induced production of TRAb and IgM at 100 nM estradiol (pregnant level) was lower than that at 0 nM estradiol and that class switch recombination may be increased by estradiol. In this study, we examined the effect of estradiol on EBV reactivation. We identified the expression of EBV-glycoprotein 350/220 (gp350/220) in the late phase of reactivation and plasma cell differentiation of EBV-infected cells using 72A1 antibody and CD138 antibody, respectively. We found the mean ratio of gp 350/220(+) CD138(+) cells at 100 nM estradiol was higher than that at 0 nM estradiol. These results suggested that EBV-infected cells could survive with keeping the ability of antibody production in 100 nM estradiol, which is consistent with the improvement of Graves' disease during maternity and exacerbation postpartum.
- Subjects
ESTRADIOL; B cells; GRAVES' disease; IMMUNOGLOBULINS; PUERPERIUM
- Publication
Yonago Acta Medica, 2019, Vol 62, Issue 2, p240
- ISSN
0513-5710
- Publication type
Article
- DOI
10.33160/yam.2019.06.010