We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Molecular characterization of cell types in the developing, mature, and regenerating fish retina.
- Authors
Bejarano-Escobar, Ruth; Blasco, Manuel; Martín-Partido, Gervasio; Francisco-Morcillo, Javier
- Abstract
The fish retina has become a powerful model system for the study of different aspects of development and regeneration. An important aspect in understanding retinal anatomy and function is to trace the development of various cell types during embryonic stages. Several markers that detect the cessation of proliferative activity have been used in studies of cellular birth days, in order to follow the temporal progression of retinogenesis. Moreover, by using cell type-specific markers, the onset of differentiation can be determined by identifying the earliest time points for which immunolabeling is observed. Additionally, fish retinal regeneration research holds the potential of providing new avenues for the treatment of degenerative diseases of the retina. Retinal markers constitute powerful tools in studies of retinal regeneration, because they allow characterization of the cell types involved in nerve tissue regeneration, providing insights into different aspects of this process. In this review, after presenting several structural and histological aspects of the mature and developing fish visual system, data on the use of various neurochemical markers specifically indicating cell types of the fish neural retina are summarized. This will be done through a review of the pertinent literature, as well as by drawing on our own experience gathered through recent studies on fish retinogenesis.
- Subjects
FISH physiology; RETINAL development; MOLECULAR biology; RETINA physiology; RETINAL anatomy; GENETIC markers; IMMUNOHISTOCHEMISTRY
- Publication
Reviews in Fish Biology & Fisheries, 2014, Vol 24, Issue 1, p127
- ISSN
0960-3166
- Publication type
Article
- DOI
10.1007/s11160-013-9320-z