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- Title
Left and right ventricular global longitudinal strain assessment together with biomarker evaluation may have a predictive and prognostic role in patients qualified for hematopoietic stem cell transplantation due to hematopoietic and lymphoid malignancies – a pilot study description
- Authors
Puła, Bartosz; Kępski, Jarosław; Misiewicz-Krzemińska, Irena; Szmit, Sebastian
- Abstract
The hematopoietic stem cell transplantation (HSCT) procedure is considered a cardiovascular burden. This is due to the potentially cardiotoxic cytostatic agents used before and the risks associated with peri-transplant procedures. We designed a pilot study to determine the clinical utility of the new ST2 marker; furthermore, we routinely assessed cardiac parameters in HSCT recipients. Based on previous cardio-oncology experience in lung and prostate cancer, we can confirm the prognostic and predictive value of classic cardiac biomarkers and modern echocardiography parameters such as global longitudinal strain of the left and right ventricle. After conducting this pilot study we can create a predictive and prognostic model for patients undergoing HSCT. This will greatly enrich our clinical practice, especially in treating older people.
- Subjects
PROSTATE tumors treatment; BIOMARKERS; LEFT heart ventricle; PILOT projects; ECHOCARDIOGRAPHY; FLOW cytometry; CARDIO-oncology; RIGHT heart ventricle; GLOBAL longitudinal strain; ENZYME-linked immunosorbent assay; RESEARCH funding; PREDICTION models; HEMATOPOIETIC stem cell transplantation; TUMORS; CYTOTOXINS
- Publication
Cardio-Oncology, 2024, Vol 10, Issue 1, p1
- ISSN
2057-3804
- Publication type
Article
- DOI
10.1186/s40959-024-00210-8