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- Title
Motor nerve excitability after childhood Guillain-Barré syndrome.
- Authors
Drenthen, Judith; Roodbol, Joyce; Maathuis, Ellen M.; Catsman‐Berrevoets, Coriene E.; Blok, Joleen H.; de Wit, Marie‐Claire Y.; Jacobs, Bart C.
- Abstract
Residual motor nerve dysfunction after pediatric Guillain-Barré syndrome (GBS) was determined in an observational cross-sectional cohort study in patients who previously developed GBS during childhood (<18 years). Ulnar motor nerve dysfunction was defined by compound motor action potential (CMAP) scan in patients after a follow up of at least 1 year compared with age-matched healthy controls, in relation to clinical course and outcome. A total of 37 persons previously diagnosed with GBS in childhood were included with a mean age at current examination of 20.6 years (4-39 years). The median time between diagnosis and follow-up was 11 years (range: 1-22 years). CMAP scanning indicated ulnar motor nerve dysfunction in 25 (68%) participants. The most frequent abnormality was a reduction in nerve excitability observed both in those with residual limb weakness and in the majority of those with complete recovery. CMAP scan characteristics were not related to prognostic factors or outcome. In conclusion, GBS in childhood results in residual motor nerve excitability disturbances, even in those completely recovered, probably reflecting altered physiology of regenerated peripheral nerves.
- Subjects
DEMYELINATION; PATIENT aftercare; MEDICAL care; MOTOR ability; PATIENTS; PEDIATRICS; GUILLAIN-Barre syndrome; RESEARCH funding; CONTROL groups; CROSS-sectional method; DISEASE duration; DISEASE complications; SYMPTOMS; DIAGNOSIS
- Publication
Journal of the Peripheral Nervous System, 2017, Vol 22, Issue 2, p100
- ISSN
1085-9489
- Publication type
Article
- DOI
10.1111/jns.12213