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- Title
CD8<sup>+</sup> recent thymic emigrants home to and efficiently repopulate the small intestine epithelium.
- Authors
Staton, Tracy L.; Habtezion, Aida; Winslow, Monte M.; Sato, Tohru; Love, Paul E.; Butcher, Eugene C.
- Abstract
Prevailing knowledge dictates that naive αβ T cells require activation in lymphoid tissues before differentiating into effector or memory T cells capable of trafficking to nonlymphoid tissues. Here we demonstrate that CD8+ recent thymic emigrants (RTEs) migrated directly into the small intestine. CCR9, CCL25 and α4β7 integrin were required for gut entry of CD8+ RTEs. After T cell receptor stimulation, intestinal CD8+ RTEs proliferated and acquired a surface phenotype resembling that of intraepithelial lymphocytes. CD8+ RTEs efficiently populated the gut of lymphotoxin-α-deficient mice, which lack lymphoid organs. These studies challenge the present understanding of naive αβ T cell trafficking and suggest that RTEs may be involved in maintaining a diverse immune repertoire at mucosal surfaces.
- Subjects
T cells; LYMPHOCYTES; CELL-mediated lympholysis; NONLYMPHOID leukemia; GASTROINTESTINAL hormones; CELL membranes
- Publication
Nature Immunology, 2006, Vol 7, Issue 5, p482
- ISSN
1529-2908
- Publication type
Article
- DOI
10.1038/ni1319