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- Title
Reduced L-Arginine and L-Arginine-ADMA-Ratio, and Increased SDMA after Norseman Xtreme Triathlon.
- Authors
Nyborg, Christoffer; Bonnevie-Svendsen, Martin; Melsom, Helene Støle; Melau, Jørgen; Seljeflot, Ingebjørg; Hisdal, Jonny
- Abstract
Endothelial vasodilatory function is dependent on the NO synthesis from L-arginine by endothelial NO-synthetase (eNOS). eNOS can be inhibited by asymmetric dimethylarginine (ADMA) by competitive inhibition on the binding site, and symmetric dimethylarginine (SDMA) can reduce the L-arginine availability intracellularly through competing for transport over the cellular membrane. To study the NO synthesis after prolonged exercise, we assessed circulatory L-arginine, the L-arginine/ADMA ratio, and SDMA before, after, and on the day after the Norseman Xtreme triathlon, an Ironman distance triathlon. We found significantly reduced levels of L-arginine and the L-arginine/ADMA ratio and increased levels of SDMA after the race (all p < 0.05). L-arginine rose toward baseline levels the day after the race, but ADMA increased beyond baseline levels, and SDMA remained above baseline the day after the race. The reduced levels of L-arginine and the L-arginine/ADMA ratio, and increased SDMA, after the race indicate a state of reduced capability of NO production. Increased levels of ADMA and SDMA, and reduced L-arginine/ADMA ratio, as seen the day after the race, are known risk markers of atherosclerosis and warrant further studies.
- Subjects
ARGININE; ASYMMETRIC dimethylarginine; TRIATHLON; BINDING sites; ATHEROSCLEROSIS
- Publication
Sports (2075-4663), 2021, Vol 9, Issue 9, p120
- ISSN
2075-4663
- Publication type
Article
- DOI
10.3390/sports9090120