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- Title
Cardiovascular Consequences of Skeletal Muscle Impairments in Breast Cancer.
- Authors
H. Zieff, Gabriel; W. Wagoner, Chad; Paterson, Craig; Pagan Lassalle, Patricia; T. Lee, Jordan
- Abstract
Breast cancer survivors suffer from disproportionate cardiovascular disease risk compared to age-matched controls. Beyond direct cardiotoxic effects due to treatments such as chemotherapy and radiation, breast-cancer-related reductions in skeletal muscle mass, quality and oxidative capacity may further contribute to cardiovascular disease risk in this population by limiting the ability to engage in aerobic exercise—a known promoter of cardiovascular health. Indeed, 20–30% decreases in peak oxygen consumption are commonly observed in breast cancer survivors, which are indicative of exercise intolerance. Thus, breast-cancer-related skeletal muscle damage may reduce exercise-based opportunities for cardiovascular disease risk reduction. Resistance training is a potential strategy to improve skeletal muscle health in this population, which in turn may enhance the capacity to engage in aerobic exercise and reduce cardiovascular disease risk.
- Subjects
SKELETAL muscle; BREAST cancer; CANCER survivors; RESISTANCE training; REDUCING exercises; AEROBIC exercises; EXERCISE tolerance
- Publication
Sports (2075-4663), 2020, Vol 8, Issue 6, p80
- ISSN
2075-4663
- Publication type
Article
- DOI
10.3390/sports8060080