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- Title
The safety of celecoxib in cutaneous hypersensitivity reactions with nonsteroidal anti-inflammatory drugs: a single-center care experience.
- Authors
Cakmak, Mehmet Erdem
- Abstract
Introduction: Aspirin/non-steroidal anti-inflammatory drugs (NSAIDs) are frequently prescribed, and hypersensitivity reactions to these drugs are frequently observed in clinical practice. Aim: To evaluate the safety of celecoxib in patients with a history of cutaneous hypersensitivity reactions to NSAIDs. Material and methods: A retrospective evaluation was made of a total of 113 patients with a history of cutaneous hypersensitivity reactions to NSAIDs who underwent a drug challenge test with celecoxib. The diagnosis of NSAID hypersensitivity was based on a positive oral aspirin challenge test result or a recorded and significant clinical hypersensitivity reaction to aspirin and/or other NSAID-induced reaction. Results: A total of 113 patients (40 (35.4%) male, 73 (64.6%) female) with a mean age of 39.64 ±12.65 years underwent the drug challenge with celecoxib. Atopy was determined in 40 (35.4%) patients. The most common accompanying allergic diseases were asthma in 46 (40.7%) patients and allergic rhinitis in 37 (32.7%) patients. The most common NSAIDs responsible for the allergic reaction were diclofenac (48.7%), flurbiprofen (47.8%), ketoprofen (47.8%), and aspirin (45.1%). No allergic reaction to celecoxib was observed in any of the 113 patients who underwent the drug challenge testing. Conclusions: Celecoxib is a safe alternative drug in patients with a history of cutaneous hypersensitivity reactions to NSAIDs.
- Subjects
CYCLOOXYGENASE 2; DRUG efficacy; KRUSKAL-Wallis Test; ASTHMA; NONSTEROIDAL anti-inflammatory agents; DICLOFENAC; ONE-way analysis of variance; RETROSPECTIVE studies; ACQUISITION of data; RHINITIS; FISHER exact test; PEARSON correlation (Statistics); MEDICAL records; ASPIRIN; CHI-squared test; DRUG allergy; FLURBIPROFEN; DATA analysis software; PATIENT safety
- Publication
Polish Journal of Allergology / Alergologia Polska, 2022, Vol 9, Issue 4, p250
- ISSN
2353-3854
- Publication type
Article
- DOI
10.5114/pja.2022.122005