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- Title
Correlation between cyclooxygenase-2 expression and body mass index on prognosis and survival of colorectal cancer of Egyptian patients.
- Authors
Gharib, Fatma; abd el aziz Mohamed, Dareen; Mohamed, Lamiss
- Abstract
Introduction: The biologic behavior of colorectal cancer is complicated. In clinical studies, elevation ofcyclooxygenase-2 (COX-2) expression was detected in colorectal cancers when compared to the adjacent normal colonic mucosa. Moreover, obesity has been reported to cause 20% of all malignancy and contributed to almost 11% of colorectal carcinoma. Egypt Demographic Survey (2008) reported high rate of obesity among Egyptians. Both COX-2 overexpression and obesity support the different mechanisms of association between chronic inflammation and carcinogenesis. The association between clincopathological characteristics and COX-2 overexpression and Body Mass Index (BMI) together with their effect on overall survival in Colorectal Carcinoma (CRC) will be evaluated in this study. Methods: Seventy-one non-metastatic CRC patients were prospectively included in this study. Those patients diagnosed, treated and followed up at Tanta University Hospitals. Immunohistochemistry was used to assess COX-2 expression. Body mass index was calculated at time of presentation. COX-2 expression and BMI were reported and compared with other clinicopathological criteria. Survival was assessed and compared by Kaplan-Meier curves and log-rank test. Results: COX-2 overexpression was detected in 49.3% of patients and significantly correlated with tumor grade (p=0.003), lymph node metastasis (p<0.001), BMI>30kg/m² (p=0.001) and gender (p<0.001). Univariate analysis revealed that COX-2 overexpression, higher grade of tumor, and high preoperative CEA status, were significantly associated with shorter overall survival. While in multivariate analysis, high COX-2 expression and tumor grade remained statistically significant with overall survival in [p =0.048; 95%CI (1.010: 12.757); HR=3.59) and p=0.034; 95%CI (1.086: 8.153); HR=2.976) respectively]. In this study, BMI>30kg/m² was reported in 53.5% of CRC cases and significantly correlated with older patients (p=0.015), femalegender (p =0.003) and lymph node involvement (p<0.001). However, no significant correlation was detected between high BMI and overall survival by univariate analysis. Conclusion: Our study showed that COX-2 overexpression in addition to obesity, significantly associated with tumor characteristics and survival of CRC patients.
- Subjects
BODY mass index; COLORECTAL cancer; CANCER patients; LYMPHATIC metastasis; OLDER patients; HUMAN carcinogenesis; DEMOGRAPHIC surveys
- Publication
Onkologia i Radioterapia, 2020, Issue 1, p21
- ISSN
1896-8961
- Publication type
Article