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- Title
Synthesis and Biological Activity of 2-Aryl-4-hydroxy-4-methyl-6-oxocyclohexane-1,3-dicarboxamides.
- Authors
Nosova, N. V.; Lezhnina, D. D.; Gein, O. N.; Novikova, V. V.; Gein, V. L.
- Abstract
The reaction of unsubstituted acetoacetamide with aromatic aldehydes in ethanol in the presence of piperidine gave 2-aryl-4-hydroxy-4-methyl-6-oxocyclohexane-1,3-dicarboxamides and 4-aryl-5-acetyl-2-hydroxy-2-methyl-6-oxopiperidine-3-carboxamides. Structures of the obtained compounds were proved using IR, 1H and 13C NMR spectroscopy methods. The synthesized compounds were tested for antimicrobial and analgesic activities.
- Subjects
BIOSYNTHESIS; NUCLEAR magnetic resonance spectroscopy; PIPERIDINE; AROMATIC aldehydes
- Publication
Russian Journal of General Chemistry, 2020, Vol 90, Issue 10, p1817
- ISSN
1070-3632
- Publication type
Article
- DOI
10.1134/S1070363220100011