We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Brainstem astroblastoma with MN1 translocation.
- Authors
Shin, Sun Ah; Ahn, Bokyung; Kim, Seung‐Ki; Kang, Hyoung Jin; Nobusawa, Sumihito; Komori, Takashi; Park, Sung‐Hye
- Abstract
Astroblastoma is a rare glial neoplasm that occurs mostly in the cerebral hemisphere of children, adolescents and young adults. Although astroblastic perivascular pseudorosettes are unique histopathology of this neoplasm, diagnosis is usually challenging. Recently, it was discovered that the meningioma 1 gene (MN1)‐altered pediatric central nervous system high‐grade neuroepithelial tumors are actually astroblastomas. This case report presents a rare brainstem astroblastoma, with an unusual immunoprofile: negative for glial fibrillary acidic protein and oligodendrocyte transcription factor 2, but with a robust expression of pancytokeratin and epithelial membrane antigen. The diagnosis was confirmed based on the detection of MN1 rearrangement in a fluorescence in situ hybridization study, in addition to typical histopathology. Here we discuss the diagnostic pitfalls and unclear grading system along with a literature review.
- Subjects
TUMOR diagnosis; HISTOPATHOLOGY; MENINGIOMA; GENE rearrangement; OLIGODENDROGLIA; CENTRAL nervous system
- Publication
Neuropathology, 2018, Vol 38, Issue 6, p631
- ISSN
0919-6544
- Publication type
Case Study
- DOI
10.1111/neup.12514