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- Title
Plasma Carbonic Anhydrase II protein is Elevated in Alzheimer's Disease.
- Authors
Bong Geom Jang; Sang-Moon Yun; Kyungsook Ahn; Ju Hee Song; Sangmee A. Jo; Young-Yul Kim; Doh Kwan Kim; Moon Ho Park; Changsu Han; Young Ho Koh
- Abstract
Carbonic anhydrase (CA) plays a critical role in pH regulation, long-term synaptic transformation, and is associated with mental retardation, Alzheimer's disease (AD), and Down syndrome. There is accumulating evidence that CAII is increased in AD brain. The present study focused on the determination of CAII protein level in blood plasma samples using immunoblot and ELISA methods. We compared plasma from 91 AD patients (average age 74.8 y), 83 persons with amnestic mild cognitive impairment (MCI) (average age 73.7 y), and 113 cognitively normal controls (average age 70.8 y). The plasma level of CAII was significantly increased in AD patients, as compared to control groups. CAII levels were higher in males than females. There was an age-dependent increase of CAII. These results provide further evidence that changes in CAII level may play a role in the pathogenesis of AD.
- Subjects
ALZHEIMER'S disease; CARBONIC anhydrase; INTELLECTUAL disabilities; DOWN syndrome; PROTEINS
- Publication
Journal of Alzheimer's Disease, 2010, Vol 21, Issue 3, p939
- ISSN
1387-2877
- Publication type
Article
- DOI
10.3233/JAD-2010-100384