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- Title
Bis (thiosemicarbazonato) Cu-64 Complexes for Positron Emission Tomography Imaging of Alzheimer's Disease.
- Authors
Fodero-Tavoletti, Michelle T.; Villemagne, Victor L.; Paterson, Brett M.; White, Anthony R.; Qiao-Xin Li; Camakaris, James; O'Keefe, Graeme J.; Cappai, Roberto; Barnham, Kevin J.; Donnelly, Paul S.
- Abstract
A bis (thiosemicarbazonato) complex radiolabeled with positron emitting Cu-64 can be used for a new and alternative method for the non-invasive diagnosis of Alzheimer's disease using positron emission tomography (PET). Most imaging agents being investigated for the diagnosis of Alzheimer's disease target plaque burden but our new approach highlights altered copper homeostasis. This approach has the potential to offer complementary information to other diagnostic procedures that elucidate plaque burden.
- Subjects
POSITRON emission; POSITRON emission tomography; ALZHEIMER'S disease research; COPPER research; HOMEOSTASIS
- Publication
Journal of Alzheimer's Disease, 2010, Vol 20, Issue 1, p49
- ISSN
1387-2877
- Publication type
Article
- DOI
10.3233/JAD-2010-1359