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- Title
The Role of Toll and Nonnuclear NF-κB Signaling in the Response to Alcohol.
- Authors
Atkinson, Nigel S.
- Abstract
An understanding of neuroimmune signaling has become central to a description of how alcohol causes addiction and how it damages people with an AUD. It is well known that the neuroimmune system influences neural activity via changes in gene expression. This review discusses the roles played by CNS Toll-like receptor (TLR) signaling in the response to alcohol. Also discussed are observations in Drosophila that show how TLR signaling pathways can be co-opted by the nervous system and potentially shape behavior to a far greater extent and in ways different than generally recognized. For example, in Drosophila, TLRs substitute for neurotrophin receptors and an NF-κB at the end of a TLR pathway influences alcohol responsivity by acting non-genomically.
- Subjects
ALCOHOL; ALCOHOLISM; NEUROTROPHIN receptors; DROSOPHILA; NERVOUS system; CELLULAR signal transduction; TOLL-like receptors; TOLLS; DRUNK driving
- Publication
Cells (2073-4409), 2023, Vol 12, Issue 11, p1508
- ISSN
2073-4409
- Publication type
Article
- DOI
10.3390/cells12111508