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- Title
Inflammation during Percutaneous Coronary Intervention—Prognostic Value, Mechanisms and Therapeutic Targets.
- Authors
Tucker, Bradley; Vaidya, Kaivan; Cochran, Blake J.; Patel, Sanjay
- Abstract
Periprocedural myocardial injury and myocardial infarction (MI) are not infrequent complications of percutaneous coronary intervention (PCI) and are associated with greater short- and long-term mortality. There is an abundance of preclinical and observational data demonstrating that high levels of pre-, intra- and post-procedural inflammation are associated with a higher incidence of periprocedural myonecrosis as well as future ischaemic events, heart failure hospitalisations and cardiac-related mortality. Beyond inflammation associated with the underlying coronary pathology, PCI itself elicits an acute inflammatory response. PCI-induced inflammation is driven by a combination of direct endothelial damage, liberation of intra-plaque proinflammatory debris and reperfusion injury. Therefore, anti-inflammatory medications, such as colchicine, may provide a novel means of improving PCI outcomes in both the short- and long-term. This review summarises periprocedural MI epidemiology and pathophysiology, evaluates the prognostic value of pre-, intra- and post-procedural inflammation, dissects the mechanisms involved in the acute inflammatory response to PCI and discusses the potential for periprocedural anti-inflammatory treatment.
- Subjects
PERCUTANEOUS coronary intervention; PROGNOSIS; DRUG target; HEART failure; INFLAMMATION; ONE-way analysis of variance; MYOCARDIAL reperfusion
- Publication
Cells (2073-4409), 2021, Vol 10, Issue 6, p1391
- ISSN
2073-4409
- Publication type
Article
- DOI
10.3390/cells10061391