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- Title
Efficient Synthesis of 3-Sulfonyl-2-sulfonylmethyl-2 H -chromenes via Tandem Knoevenagel Condensation/Oxa-Michael Addition Protocol.
- Authors
Jiang, Lin; Peng, Peiying; Li, Min; Li, Lu; Zhao, Menglin; Yuan, Minglong; Yuan, Mingwei
- Abstract
An organocatalytic [4 + 2] cascade annulation of salicylaldehydes and 1,3-bisarylsulfonylpropenes has been developed. This protocol enables the efficient and straightforward synthesis of a new series of 3-sulfonyl-2-sulfonylmethyl-2H-chromenes that are useful for exploring pharmacologically valued compounds. Further reductive modifications result in 3-desulfonylated chromene or chromane derivatives. This protocol can be expanded to the synthesis of 3-sulfonyl-2-sulfonylmethyl 1,2-dihydroquinoline.
- Subjects
ANNULATION; ORGANOCATALYSIS
- Publication
Catalysts (2073-4344), 2022, Vol 12, Issue 5, p491
- ISSN
2073-4344
- Publication type
Article
- DOI
10.3390/catal12050491