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- Title
Anti-Ma2 Antibody-Associated Paraneoplastic Neurological Syndromes: A Pilot Study.
- Authors
Guo, Yi; Cai, Meng-Ting; Lai, Qi-Lun; Zheng, Yang; Shen, Chun-Hong; Zhang, Yin-Xi
- Abstract
Paraneoplastic neurologic syndromes (PNSs) are a heterogeneous group of disorders caused by the remote effects of cancer with immune-mediated pathogenesis. Anti-Ma2 antibody was defined as one of the well-characterized onconeural antibodies that could help establish a definite PNS diagnosis. We aimed to report and explore patients with anti-Ma2 antibody-associated paraneoplastic neurologic syndrome (Ma2-PNS) who frequently exhibit sensorimotor neuropathy (SMN) using a new method of factor analysis of mixed data (FAMD). Clinical data from a case series of eight patients with definite diagnoses were retrospectively reviewed. FAMD conducted further analyses with a comprehensive visualization in R software. Our cohort, with a predominance of females (5/8), presented more frequently with SMN (4/8), followed by limbic encephalitis (LE) (3/8). Two patients with LE were found to have a testicular germ-cell tumor and a thymoma, respectively. In addition, a patient who developed chronic SMN was diagnosed with multiple myeloma (MM) involving multiple organs. FAMD exhibited the overall features into a two-dimensional coordinate and located each individual into their corresponding position with high relevance. It provided a clue for determining their potential relationships and predictors. Our findings indicated that Ma2-PNS could frequently involve the peripheral nervous system, MM might be one of its associated cancers with a presentation of chronic SMN, and FAMD might be a clinically valuable tool.
- Subjects
PARANEOPLASTIC syndromes; PERIPHERAL nervous system; MULTIPLE myeloma; FACTOR analysis; PILOT projects; CARCINOGENESIS
- Publication
Brain Sciences (2076-3425), 2021, Vol 11, Issue 12, p1577
- ISSN
2076-3425
- Publication type
Article
- DOI
10.3390/brainsci11121577