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- Title
Use of Swedish smokeless tobacco (snus) and the risk of Type 2 diabetes and latent autoimmune diabetes of adulthood ( LADA).
- Authors
Rasouli, B.; Andersson, T.; Carlsson, P.‐O.; Grill, V.; Groop, L.; Martinell, M.; Midthjell, K.; Storm, P.; Tuomi, T.; Carlsson, S.
- Abstract
Aims It has been suggested that moist snuff (snus), a smokeless tobacco product that is high in nicotine and widespread in Scandinavia, increases the risk of Type 2 diabetes. Previous studies are however few, contradictory and, with regard to autoimmune diabetes, lacking. Our aim was to study the association between snus use and the risk of Type 2 diabetes and latent autoimmune diabetes of adulthood ( LADA). Method Analyses were based on incident cases (Type 2 diabetes, n = 724; LADA, n = 200) and population-based controls ( n = 699) from a Swedish case-control study. Additional analyses were performed on cross-sectional data from the Norwegian HUNT study ( n = 21 473) with 829 prevalent cases of Type 2 diabetes. Odds ratios ( OR) were estimated adjusted for age, BMI family history of diabetes and smoking. Only men were included. Results No association between snus use and Type 2 diabetes or LADA was seen in the Swedish data. For Type 2 diabetes, the OR for > 10 box-years was 1.00 [95% confidence interval ( CI), 0.47 to 2.11] and for LADA 1.01 (95% CI, 0.45 to 2.29). Similarly, in HUNT, the OR for Type 2 diabetes in ever-users was estimated at 0.91 (95% CI, 0.75 to 1.10) and in heavy users at 0.92 (95% CI, 0.46 to 1.83). Conclusion The risk of Type 2 diabetes and LADA is unrelated to the use of snus, despite its high nicotine content. This opens the possibility of the increased risk of Type 2 diabetes seen in smokers may not be attributed to nicotine, but to other substances in tobacco smoke.
- Subjects
NORWAY; SWEDEN; SNUS (Tobacco); TYPE 2 diabetes risk factors; TYPE 1 diabetes; CONFIDENCE intervals; RESEARCH funding; STATISTICAL sampling; LOGISTIC regression analysis; CROSS-sectional method; GLUCOSE intolerance; ODDS ratio; DIABETES risk factors
- Publication
Diabetic Medicine, 2017, Vol 34, Issue 4, p514
- ISSN
0742-3071
- Publication type
Article
- DOI
10.1111/dme.13179