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- Title
A Role for siRNA in X-Chromosome Dosage Compensation in Drosophila melanogaster.
- Authors
Menon, Debashish U.; Meller, Victoria H.
- Abstract
Sex-chromosome dosage compensation requires selective identification of X chromatin. How this occurs is not fully understood. We show that small interfering RNA (siRNA) mutations enhance the lethality of males deficient in X recognition and partially rescue females that inappropriately dosage-compensate. Our findings are consistent with a role for siRNA in selective recognition of X chromatin.
- Subjects
SMALL interfering RNA; X chromosome; SEX chromosomes; DROSOPHILA melanogaster; CHROMATIN; GENETIC mutation
- Publication
Genetics, 2012, Vol 191, Issue 3, p1023
- ISSN
0016-6731
- Publication type
Article
- DOI
10.1534/genetics.112.140236