Reports on the suppression of loss of function of Saccharomyces cerevisiae kinesin-related CIN8 and KIP1 by KAR3 motor domain mutations. Extragenic suppressors as alleles of the KAR3 gene; KAR3 encoding of a distinct kinesin-related protein which antagonizes Cin8p/Kip1p function; Suppressing alleles not null for function.