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- Title
d-Ribose improves diastolic function and quality of life in congestive heart failure patients: a prospective feasibility study
- Authors
Omran, Heyder; Illien, Stefan; MacCarter, Dean; St. Cyr, John; Lüderitz, Berndt; Lüderitz, Berndt
- Abstract
Patients with chronic coronary heart disease often suffer from congestive heart failure (CHF) despite multiple drug therapies. d-Ribose has been shown in animal models to improve cardiac energy metabolism and function following ischaemia. This was a prospective, double blind, randomized, crossover design study, to assess the effect of oral d-ribose supplementation on cardiac hemodynamics and quality of life in 15 patients with chronic coronary artery disease and CHF. The study consisted of two treatment periods of 3 weeks, during which either oral d-ribose or placebo was administered followed by a 1-week wash out period, and then administration of the other supplement. Assessment of myocardial functional parameters by echocardiography, quality of life using the SF-36 questionnaire and functional capacity using cycle ergometer testing was performed. The administration of d-ribose resulted in an enhancement of atrial contribution to left ventricular filling (40±11 vs. 45±9%, P=0.02), a smaller left atrial dimension (54±20 vs. 47±18 ml, P=0.02) and a shortened E wave deceleration (235±64 vs. 196±42, P=0.002) by echocardiography. Further, d-ribose also demonstrated a significant improvement of the patient''s quality of life (417±118 vs. 467±128, P⩽0.01). In comparison, placebo did not result in any significant echocardiographic changes or in quality of life. This feasibility study in patients with coronary artery disease in CHF revealed the beneficial effects of d-ribose by improving diastolic functional parameters and enhancing quality of life.
- Subjects
CONGESTIVE heart failure; HEART failure; RIBOSE; PENTOSES; QUALITY of life
- Publication
European Journal of Heart Failure, 2003, Vol 5, Issue 5, p615
- ISSN
1388-9842
- Publication type
journal article
- DOI
10.1016/S1388-9842(03)00060-6