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- Title
Interleukin-15 treatment improves glucose homeostasis and insulin sensitivity in obese mice.
- Authors
Barra, N. G.; Chew, M. V.; Holloway, A. C.; Ashkar, A. A.
- Abstract
The prevalence of metabolic diseases associated with obesity, such as type 2 diabetes, continues to rise along with obesity rates. Recently, obesity has been described as an inflammatory condition, suggesting a link between the dysregulation in proinflammatory cytokine production and the aetiology of these metabolic diseases. While known as an immunomodulatory cytokine, Interleukin-15 (IL-15) has been shown to have effects on adipose tissue and induce weight loss in diet-induced obese mice. As weight loss improves glucose homeostasis, the goal of this study was to determine whether IL-15 impacts glucose regulation in a mouse model of diet-induced obesity. Our data demonstrate that IL-15 treatment significantly improves insulin sensitivity and glucose and insulin responses to an oral glucose challenge compared to obese counterparts and/or lean controls. These results show that IL-15 may be a novel therapeutic target for the treatment of obesity and its associated abnormal glucose regulation.
- Subjects
EXPERIMENTAL pharmacology; GLUCOSE metabolism; INSULIN resistance; OBESITY treatment; LABORATORY mice
- Publication
Diabetes, Obesity & Metabolism, 2012, Vol 14, Issue 2, p190
- ISSN
1462-8902
- Publication type
Article
- DOI
10.1111/j.1463-1326.2011.01495.x