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- Title
Fetuin- A-containing calciprotein particle levels can be reduced by dialysis, sodium thiosulphate and plasma exchange. Potential therapeutic implications for calciphylaxis?
- Authors
Cai, Michael MX; Smith, Edward R; Brumby, Catherine; McMahon, Lawrence P; Holt, Stephen G
- Abstract
Calciprotein particles ( CPP) are a novel marker of mineral stress. High levels of CPP are found in patients with calciphylaxis, a condition associated with marked vascular calcification and a poor prognosis. We report substantial reductions in CPP levels in a dialysis patient having combined haemodialysis ( HD) and plasma exchange ( PEx) prior to an ABO-incompatible kidney transplant. We also report the effects of the same treatments combined with sodium thiosulphate ( STS) in a patient newly diagnosed with calciphylaxis. Combining HD with intra-dialytic STS and PEx we achieved a significant reduction in CCP with the least rebound between treatment sessions. After 6 weeks of treatment, the CPP reduction was paralleled by clinical improvement. Measurement of CPP may be an attractive marker for monitoring the effectiveness of calciphylaxis therapy.
- Subjects
ALPHA fetoproteins; DIALYSIS (Chemistry); BLOOD plasma; CALCIPHYLAXIS; THERAPEUTICS
- Publication
Nephrology, 2013, Vol 18, Issue 11, p724
- ISSN
1320-5358
- Publication type
Article
- DOI
10.1111/nep.12137