We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Ropivacaine in the horse: its pharmacological responses, urinary detection and mass spectral confirmation.
- Authors
Harkins, J. D.; Karpiesiuk, W.; Lehner, A.; Woods, W. E.; Dirikolu, L.; Carter, W. G.; Boyles, J.; Tobin, T.
- Abstract
This report evaluates the pharmacological responses, urinary detection and mass spectral confirmation of ropivacaine in horses. Ropivacaine, a potent local anesthetic (LA) recently introduced in human medicine, has an estimated highest no-effect dose (HNED) of about 0.4 mg/site as determined in our abaxial sesamoid block model. Apparent ropivacaine equivalents were detectable by ELISA screening using a mepivacaine ELISA test after administration of clinically effective doses. Mass spectral examination of postadministration urine samples showed no detectable parent ropivacaine, but a compound indistinguishable from authentic 3-hydroxyropivacaine was recovered from these samples. The study shows that ropivacaine is a potent LA in the horse, that clinically effective doses can be detected in postadministration samples by ELISA-based screening, and that its major post administration urinary metabolite is 3-hydroxyropivacaine.
- Subjects
LOCAL anesthetics; PHARMACOKINETICS; ENZYME-linked immunosorbent assay; PHYSIOLOGY
- Publication
Journal of Veterinary Pharmacology & Therapeutics, 2001, Vol 24, Issue 2, p89
- ISSN
0140-7783
- Publication type
Article
- DOI
10.1046/j.1365-2885.2001.00314.x