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- Title
Interspecies comparisons of plasma half-life of trimethoprim in relation to body mass.
- Authors
PASHOV, D.A.; LASHEV, L.D.; MATEV, I.B.; KANELOV, I.N.
- Abstract
The relationship between body mass and plasma half-life of trimethoprim was studied in 10 different species of animals and man using published data. Log half-life was positively and significantly correlated to log body mass based on individual measurements in herbivorous animals ( n=23, P<0.01), in herbivorous animals+pigs ( n=29, P<0.01), in ungulates ( n=27, P<0.01), in ruminants ( n=16, P<0.01) and in non-herbivorous mammals, except pigs ( n=6, P<0.05). The correlation was described by the allometric equations: t½β=27 W0.26 in herbivorous animals and t½β=125 W0.32 in non-herbivorous animals except pigs.
- Publication
Journal of Veterinary Pharmacology & Therapeutics, 1997, Vol 20, Issue 1, p48
- ISSN
0140-7783
- Publication type
Article
- DOI
10.1046/j.1365-2885.1997.00042.x