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- Title
Functional dyspepsia impairs quality of life in the adult population.
- Authors
Aro, P.; Talley, N. J.; Agréus, L.; Johansson, S.‐E.; Bolling‐Sternevald, E.; Storskrubb, T.; Ronkainen, J.
- Abstract
Background Data on the impact of functional dyspepsia on health-related quality of life in the general adult population are scarce. Aim To explore the impact of functional dyspepsia applying the Rome III definition on health-related quality of life in the general population. Method A random sample of an adult Swedish population (n = 1001, The Kalixanda study) was invited to undergo an oesophagogastroduodenoscopy. An extended abdominal symptom questionnaire and Short Form-36 (SF-36) questionnaire, which includes eight domains measuring physical, mental and social aspects of quality of life, were completed at the clinic visit just before oesophagogastroduodenoscopy. Results Two hundred and two (20%) individuals reported uninvestigated dyspepsia (UID), 157 (16%) functional dyspepsia (FD), 52 (5%) epigastric pain syndrome (EPS) and 122 (12%) postprandial distress syndrome (PDS). UID, FD and PDS had a clinically meaningful (a ≥ 5 point) and statistically significant impact (P < 0.05) on health-related quality of life in all SF-36 domains except for Role Emotional. EPS had a significant impact on Bodily Pain and Vitality. Overlap of FD with irritable bowel syndrome (IBS) had a significant impact on Bodily Pain (P = 0.002) and General Health (P = 0.02) while FD overlap with gastro-oesophageal reflux symptoms (GERS) had a significant impact on Bodily Pain (P = 0.02) compared with FD without any overlap with IBS or GERS. Conclusion Functional dyspepsia impacts all main domains describing physical, mental and social aspects of health-related quality of life in the general population. Overlap of functional dyspepsia with irritable bowel syndrome or gastrooesophageal reflux symptoms impacts the domain related to bodily pain.
- Subjects
INDIGESTION; QUALITY of life; PUBLIC health; IRRITABLE colon; GASTROINTESTINAL diseases
- Publication
Alimentary Pharmacology & Therapeutics, 2011, Vol 33, Issue 11, p1215
- ISSN
0269-2813
- Publication type
Article
- DOI
10.1111/j.1365-2036.2011.04640.x