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- Title
Expression Analysis of Long Non-Coding PCAT-1 in Breast Cancer.
- Authors
Sarrafzadeh, Shaghayegh; Geranpayeh, Lobat; Ghafouri-Fard, Soudeh
- Abstract
Background: The prostate cancer-associated non-coding RNA transcript 1 (PCAT-1) is a newly identified long non- coding RNA whose participation in tumorigenesis of a variety of cancers has been observed. In the present study, we aimed at analysis of its expression in breast cancer patients. Materials and Methods: The expression of PCAT-1 was assessed using real-time reverse transcription polymerase chain reaction in tumor samples obtained from 47newly diagnosed breast cancer patients as well as their corresponding adjacent non-cancerous tissues (ANCTs). Results: We detected significant over-expression of PCAT-1 in 12/47 (25.5%) of tumoral tissues compared with their corresponding ANCTs. However, no significant association has been found between the levels of PCAT-1 transcripts and patients' clinical data such as tumor size, stage, grade, estrogen and progesterone receptors or Her2/neu status. Conclusion: PCAT-1 is possibly involved in the pathogenesis of fraction of breast cancers. Future studies are needed to evaluate its precise function in breast cancer.
- Subjects
BREAST cancer; NON-coding RNA; NEOPLASTIC cell transformation; BREAST cancer patients; CANCER
- Publication
International Journal of Hematology-Oncology & Stem Cell Research, 2017, Vol 11, Issue 3, p185
- ISSN
2008-3009
- Publication type
Article