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- Title
n6-methyladenosine-modified circular RNA family with sequence similarity 126, member A affects cholesterol synthesis and malignant progression of prostate cancer cells by targeting microRNA-505-3p to mediate calnexin.
- Authors
Lin Luo; Ping Li; QingZhi Xie; YunChou Wu; FuQiang Qin; DunMing Liao; Ke Zeng; KangNing Wang
- Abstract
This article, published in the Journal of Cancer, explores the role of a specific circular RNA (circFAM126A) in prostate cancer (PCa). The study found that circFAM126A is upregulated in PCa and promotes the progression of the disease. It also identified that circFAM126A targets microRNA-505-3p to mediate calnexin, which affects cholesterol synthesis and malignant progression in PCa cells. The findings suggest that circFAM126A could be a potential therapeutic target for the treatment of PCa. Additionally, the article discusses the expression and potential role of circFAM126A as a biomarker for PCa prognosis. Another document discusses the role of circFAM126A in promoting PCa and its interaction with miR-505-3p and CANX. The study found that circFAM126A promotes PCa cell proliferation, migration, and invasion, while also inhibiting apoptosis. It was also discovered that circFAM126A interacts with miR-505-3p and acts as a sponge for it. miR-505-3p, in turn, inhibits the malignant progression of PCa cells. Additionally, CANX was identified as a target gene of miR-505-3p. These findings suggest that circFAM126A and miR-505-3p play important roles in the development and progression of PCa. Another article discusses the role of circFAM126
- Subjects
METHYLADENINE-DNA glycosylase; RNA sequencing; CHOLESTEROL; PROSTATE cancer; CALNEXIN
- Publication
Journal of Cancer, 2024, Vol 15, Issue 4, p966
- ISSN
1837-9664
- Publication type
Article
- DOI
10.7150/jca.89135