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- Title
RP-HPLC Method Development, Validation and Stability Indicating Study of Olanzapine in Tablet Dosage Form.
- Authors
Bhatt, Rahul; Singh, Gurdeep; Tiwari, Apoorva; Jain, Neetesh K.
- Abstract
RP-HPLC method was developed for evaluation of Olanzapine in pharmaceutical formulation. The separation was conducted by using mobile phase consisting of buffer (KH2PO4): acetonitrile in the ratio of 60:40.The wavelength was found at 257.0nm and it is freely soluble in 0.1 NHCL, methanol, acetonitrile and benzene and slightly soluble in ethyl alcohol. The linearity of method was investigated in the range of 5-25 μg/ml and R.S.D was found 1.994. The aim of this research study was to develop and validate simple, accurate, precise, sensitive and cost effective RP-HPLC method for quantitative evaluation of Olanzapine drugs and to develop a validated Stability Indicating RP-HPLC method for determination of Olanzapine drug in pharmaceutical formulations which are critical for the quality control laboratories.
- Subjects
OLANZAPINE; HYDROCHLOROTHIAZIDE; ETHANOL; QUALITY control; DRUG dosage; CLINICAL drug trials
- Publication
International Journal of Pharmacy & Life Sciences, 2020, Vol 11, Issue 11, p7079
- ISSN
0976-7126
- Publication type
Article