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- Title
Non-alcoholic Fatty Liver Disease and Depression: Evidence for Genotype x Environment Interaction in Mexican Americans.
- Authors
Manusov, Eron Grant; Diego, Vincent P.; Sheikh, Khalid; Laston, Sandra; Blangero, John; Williams-Blangero, Sarah; Tarantino, Giovanni; Martins, Ian James
- Abstract
This study examines the impact of G x E interaction effects on non-alcoholic fatty liver disease (NAFLD) among Mexican Americans in the Rio Grande Valley (RGV) of South Texas. We examined potential G x E interaction using variance components models and likelihood-based statistical inference in the phenotypic expression of NAFLD, including hepatic steatosis and hepatic fibrosis (identified using vibration controlled transient elastography and controlled attenuation parameter measured by the FibroScan Device). We screened for depression using the Beck Depression Inventory-II (BDIII). We identified significant G x E interactions for hepatic fibrosis x BDI-II. These findings provide evidence that genetic factors interact with depression to influence the expression of hepatic fibrosis.
- Subjects
RIO Grande Valley (Colo.-Mexico &; Tex.); TEXAS; NON-alcoholic fatty liver disease; GENOTYPE-environment interaction; MEXICAN Americans; RANDOM effects model; FATTY liver
- Publication
Frontiers in Psychiatry, 2022, Vol 13, p1
- ISSN
1664-0640
- Publication type
Article
- DOI
10.3389/fpsyt.2022.936052